Substrates and
Reagents
Kinome Profiling Services
Compound Testing Services
Sox-based Sensor Phosphopeptides for Continuous, Homogeneous, and Quantitative Monitoring of Protein Phosphatase Activity
Protein phosphatases are critical drug targets for cancer therapy development with a need for robust assays that monitor phosphatase enzyme activity. Learn how our assays continuously monitor protein phosphatase activity.
Automated Linear Range Determination and Applications to Enzymatic Progress Curves
When interrogating protein kinases and their inhibitors, a continuous assay format allows you to confidently visualize and quantify enzyme activity across the entire progress curve. Learn about our fully automated protocol to streamline and optimize linear range finding in our latest scientific poster.
The Advantages of Kinome Profiling With a Continuous Assay
Join Earl May, Ph.D., Sr. Director of Discovery Technologies, as he delves into the unique advantages of continuous assays over their endpoint counterparts, reveals hidden insights within raw data, and demonstrates how progress curves can help you identify essential aspects of an inhibitor's mode of action.
Development of a Real-Time, Fluorescence Microplate Assay for Epidermal Growth Factor Receptor (EGFR) Tyrosine Kinase Activity
Epidermal Growth Factor Receptor (EGFR) wild-type and mutant tyrosine kinase activity and the downstream signaling cascades are pivotal in oncogenesis, drug resistance, and tumor recurrence. Learn how our team developed a continuous, real-time, fluorescence-based assay for EGFR tyrosine kinase inhibitors (TKI’s).
